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  • How to get p-value for a riskratio in meta-analysis

    I want to make meta-analysis on the impact of Covid on an outcome of a disease, expressed as a RiskRatio for complicated/noncomplicated disease during the pandemic compared with the prepandemic period. I use

    meta esize ComplicatedCovid NoncomplicatedCovid ComplicatedPre NoncomplicatedPre , esize(lnrratio)
    meta summarize, transform(exp) random subgroup(source)

    This does not give me any p-value for the pooled effect size.

    If I use only one group I get Test of theta = 0. As the expected RR=1 I want to test if theta=1

    This works well
    metan ComplicatedCovid NoncomplicatedCovid ComplicatedPre NoncomplicatedPre, rr random by(source)
    This gives me Tests of subgroup effect size = 1:

    I also want to analyse the impact on the number of observed cases during the pandemic compared to pre-pandemic period. In other words this is a ratio of two counts. Some would call it Standardized Incidence Ratio even though we have no infrmation on the catchment population.
    I have used the smrby plugin to get SIR and CI and from there I can get the SE and finally

    meta set SIR SE
    meta summarize

    But also here I get the test of Theta=0, instead of 1.

    In both cases, the confidence interval for some subgroups includes 1 but I get significant p-values

    How can I get the correct p-value for these kind of analyses.
    Last edited by rollanders; 03 Aug 2022, 11:16.

  • #2
    The incidence ratio (IR) estimates should be on the logarithm scale. The standard error should be the standard error of log(IR).
    Last edited by Tiago Pereira; 04 Aug 2022, 15:15.

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