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  • Stratified cluster randomization with 3 arms and co-variate balance

    Hi,

    Could anyone help me with conducting a unequal stratified cluster randomization to 3 arms (2 TR and 1CG).

    We are running and RCT and have 1048 individuals, spread across 42 blocks. We want to randomly assign 37% to Treatment arm 1, 37% to Treatment arm 2, and 26% to control group. at block-level. Meanwhile we want to ensure co-variate balance on 15-20 variables.

    I have 3 questions:
    1. What command can I best use to conduct this randomisation? I've tried command "cvcrand", however it does not seem to allow for more than 2 treatment arms & unequal assignment.
    2. What is the best method to verify co-variate balance after conducting this form of random assignment? I've (successfully) used the "randomizr" command. How can I test accurately for co-variate balance? ANOVA test -according to many recent articles- does not work in our case.
    Thank you for the help!

    Iris
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