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  • Meta analysis of hazard ratio

    Dear ,
    My name is Hatem Ali
    I am trying to do meta analysis of hazard ratio to assess effect of rise in IL6 on overall survival
    I have the following data
    id Sample size p value CI LOWER CI HIGHER notes
    Pecoits-Filho (HR for overall mortality,IL6 was higher in CVD group) 99 0.01 chi square=11.3
    Liu et al 50 0.001 OR=6.9
    cho et al (trend over time) 175 0.03 1.31 87.75 OR=10.72
    Lambie et al 575 0.008 1.22 3.78 HR=2.15
    Lambie et al 2 384 0.009 1.28 5.58 HR=2.68
    Wang et al(mortality and Coronary calcification) 152 0.003 1.53 8.26 HR=3.56










    As you see, I have sample size, p value, lower and higher confidence interval.
    However, only 3 studies are reporting HR, 2 are reporting OR, one is reporting chi square.

    Is there a way to calculate hazard ratio from the studies reporting odds ratio or chi square?
    In other words,can I convert Odds ratio to hazard ratio? and can I convert chi square to hazard ratio?

    If that is not possible, then , can I calculate Relative risk for each study from the data I have?
    Can I calculate RR from HR, 95% CI , sample size and P value?
    Can I calculate RR drom OR, 95%CI, sample size and P value?
    Can I calculate RR from chi square, sample size and P value?

    Finally , after calculating HR, the syntax to use is : metan HR lower higher, counts random
    is that correct?
    How can I add the name of the studies to the forest plot using this syntax?

    Looking forward to hear back from you

  • #2
    Here's a discussion you might find helpful.
    --
    Bruce Weaver
    Email: [email protected]
    Version: Stata/MP 18.5 (Windows)

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