Statistic analysis of crossover study

[Majbritt Lund]

I need help to the analysis of a study where rats were given two different treatments in a crossover design with two periods. Furthermore, rats were allocated to three different fasting groups, which were consistent through the trial.

Does anyone know how to analyse this study design?

[Carlo Lazzaro]

Majbritt:
welcome to this forum.
Posts on crossover studies appear from time to time on this list; you can spot them by putting the keyword crossover in the search window above.

[Carlo Lazzaro]

Majbritt:
have you taken a comprehensive look at -anova- entry in Stata .pdf manual?

[Rich Goldstein]

a lot depends on information you do not supply (e.g., the type of outcome variable; whether one of your treatment arms is a control, etc.); note that standard texts on crossover trials have at least one chapter each on 3-arm trials; see, e.g.,

Senn, S (2002), Cross-over Trials in Clinical Research, second edition, Wiley

Jones, B and Kenward, MG (2003), Design and analysis of cross-over trials, second edition, Chapman & Hall/CRC