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  • dose-response meta-analysis using glst and xblc

    Hello,

    I am currently working on a meta-analysis project and would like to use the glst and xblc command on multiple studies.

    I am running into some programming issues when I try to go through the steps. For some background, in one of my datasets, I have 11 studies, some have 2 exposure levels whereas some have 5 exposure levels, there are case-control studies, cohorts (both IR and CI data) and a dose variable that ranges from approximately 0-10 (with continuous like data to the tenth of a decimal place).

    Here are the commands I have followed and their corresponding outputs (in Stata v.13):

    n=controls in CC data, person years in CI data and noncases in IR data
    case= number of cases
    dose= exposure as a continuous variable
    logrr= natural log point estimate from each study and exposure level
    se= natural log standard error
    id= study id in numeric form
    study= CC for case-control coded as 1, IR for incidence rate coded as 2 and CI for cumulative incidence coded as 3


    mkspline doses = dose , nk (3) cubic

    . clist study dose doses1 doses2 in 1/5

    study dose doses1 doses2
    1. 1 0 0 0
    2. 1 .4 .4 .00256
    3. 1 1.2 1.2 .06912
    4. 1 2.7 2.7 .7724235
    5. 1 3.8 3.8 1.856052



    . glst logrr doses1 doses2 , se(se) cov( n case ) pfirst( id study )
    *: 3200 conformability error
    glsest(): - function returned error
    <istmt>: - function returned error
    r(3200);

    end of do-file

    r(3200);


    . levelsof dose
    0 .4 .5 .9 1 1.2 1.5 2 2.1 2.5 2.6 2.7 2.8 3 3.5 3.8 4 4.3 5 6.5 9.9 10 13.5

    .
    . xblc doses1 doses2, at(`r( levels )') covname( dose ) ref (0) eform line

    dose exp(xb) (95% CI)
    0 1.00 (1.00-1.00)
    value .4 of dose not observed
    r(198);

    I was wondering if you have ever run into something like this or if you have any ideas to what is going on here.

    I really appreciate your time and look forward to hearing from you!

    Thank you,
    Megan

  • #2
    Hi Megan,
    I have had similar issues and am wondering if you ever resolved yours and what was your solution.
    Many thanks,
    Alexander
    Many thanks,
    Alexander
    (Stata v14.2 IC for Mac)

    Comment


    • #3
      Hi both,

      I have had the exact same issue, did either of you find a solution.
      Would be grateful for any help.
      Thanks,
      Rachel

      Comment

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