Hello,

I would like to know how I can calculate the LD50, LD90 and LD 95 (lethal dose) for bioassays using logit regression?

I found probit regression commands, however I would like to apply the formula to STATA programming, please could someone help me?

1) For LD50 in probit and logit regression the formula is the same:

local LD50 LD50: exp (-_ b [_cons] / _ b [logdose])

2) However, for the other LD there is a change:

I found the links described at the end for the probit model as follows:

Probit: LDp = (invnormal (p) -constant) / coef

STATA command:

local ld90 LD90: exp ((invnorm (0.9) -_ b [_cons]) / _ b [logdose])

However, for the logit model the formula recommends is:

Logit: LDp = (log (p / (1-p)) - constant) / coef

How to program the above command in stata for Logit regression?

Another question is about normality: If the distribution is not normal, should I calculate LD from the Logit regression? I have read in some places that if the distribution is not parametric, logit regression should be applied for LD.

Would you have another model suggestion for calculating LD with non-normal distribution?

Thanks

LINKS:

https://www.stata.com/statalist/arch.../msg00184.html

https://www.statalist.org/forums/for...r-logit-probit

https://stats.idre.ucla.edu/other/mu...git-or-probit/

I would like to know how I can calculate the LD50, LD90 and LD 95 (lethal dose) for bioassays using logit regression?

I found probit regression commands, however I would like to apply the formula to STATA programming, please could someone help me?

1) For LD50 in probit and logit regression the formula is the same:

local LD50 LD50: exp (-_ b [_cons] / _ b [logdose])

2) However, for the other LD there is a change:

I found the links described at the end for the probit model as follows:

Probit: LDp = (invnormal (p) -constant) / coef

STATA command:

local ld90 LD90: exp ((invnorm (0.9) -_ b [_cons]) / _ b [logdose])

However, for the logit model the formula recommends is:

Logit: LDp = (log (p / (1-p)) - constant) / coef

How to program the above command in stata for Logit regression?

Another question is about normality: If the distribution is not normal, should I calculate LD from the Logit regression? I have read in some places that if the distribution is not parametric, logit regression should be applied for LD.

Would you have another model suggestion for calculating LD with non-normal distribution?

Thanks

LINKS:

https://www.stata.com/statalist/arch.../msg00184.html

https://www.statalist.org/forums/for...r-logit-probit

https://stats.idre.ucla.edu/other/mu...git-or-probit/