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  • Interrupted time series with multiple observations per individual - itsa or xtitsa?

    I am doing an interrupted time series analysis looking at initiations of a medication with the onset of the covid pandemic as the intervention date.
    This is population-level data and this medication is frequently discontinued and re-initiated, so individuals can contribute more than one "initiation" during the study period.
    We are looking at initiations per 7-day period, and consider a re-initiation to be any initiation after 30 days without being dispensed the medication.

    Appreciate the answers to these questions:
    1. Is there something I need to do to account for the correlation of data at the participant/individual level?
    2. Can I still use the itsa command or is it better to use xtitsa? Or neither are possible and I need to restrict to one entry per individual?

    Thanks for any advice!
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