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  • Full Replicate Bioequivalence

    Hello Everybody!

    First of all, I would like to thank you for all people in these forum that take your times to help Stata Users! Thank you so much!

    So, I`m a beginner in Stata, and I`m learning and practising about pharmacokinetic and bioequivalence studies and tests.

    I would like to know if Stata is capable to calculate full replicate (2x2x4) bioequivalence studies, and what function I need to use to achieve these tests.

    I already calculate the PK parameters with pkexamine and apply the other functions to pkequiv. But, the only scenario that I could measure is the cross-over 2x2, when I have RT and TR sequences.

    How could I calculate for TRR / RTTR (2x2x4) ?



    Thank you!!
    .

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