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  • Using stir to analyse IRR for cancer recurrence in two groups, p significant but CI range below 1, any thoughts?

    Dear all,

    I have a set of data with approximately 100 patiens treated for cancer in two groups in regards to increase in luteinising hormone. I have som problems understanding how the p-value can go below 0.05 when CI is 0.97 - 11.15.I know the p-value is sensitive to group size etc but I still cannot understand this result (pic below). Any ideas?

    Best regards,
    John Tapper
    . stir elev_lh_3
    failure _d: ttr
    analysis time _t: (ttr_date-origin)/30.4
    origin: time op_date
    exit on or before: time op_date+(365*5)
    id: patno
    note: Exposed <-> elev_lh_3==1 and Unexposed <-> elev_lh_3==0
    Luteinizing Hormone
    increased 50+%
    Exposed Unexposed Total
    Failure 8 6 14
    Time 971.2171 2322.796 3294.013
    Incidence rate .0082371 .0025831 .0042501
    Point estimate [95% Conf. Interval]
    Inc. rate diff. .005654 -.0004166 .0117246
    Inc. rate ratio 3.188846 .9702801 11.15018 (exact)
    Attr. frac. ex. .6864069 -.0306303 .9103153 (exact)
    Attr. frac. pop .3922325
    (midp) Pr(k>=8) = 0.0179 (exact)
    (midp) 2*Pr(k>=8) = 0.0357 (exact)

  • #2
    Just realised what my "issue" was. The topic should be deleted.

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