- If GMM in all of the four steps correctly identifies the respective coefficients, then in principle the product of coefficients methods should be applicable. You would probably need to argue with the help of a DAG that this is the case. The answer depends very much on the specific application and cannot be answered in general, I believe.
- Unit-root tests typically require a large time dimension to be reliable. If you believe in the results of your tests, this would raise questions whether a nonstationary variable can cause a stationary variable in your proposed sequence of mediator variables. Models with different integration orders of the dependent and independent variable are typically misspecified unless there are further variables in the model, e.g. lagged dependent variable and lagged independent variable, that help to obtain a stationary error term.
- Are we talking about dynamic models with a lagged dependent variable? (I have some difficulties imagining such dynamic models in the context of a mediator analysis as you described in 1.) In such dynamic models, the stationarity condition for system GMM is effectively a condition on the initial observations. In static models, this initial observations problem does not occur. However, the first differences of nonstationary variables may generally be poor instruments for the levels (and vice versa). Because these system GMM estimators are discussed almost entirely in the context of dynamic models with a short time dimension, unit-root tests are usually not considered as they would require a large time dimension.
- In the case of a FOD-transformed model only, we would not call it a system GMM estimator. You could possibly call it an FOD-GMM estimator. Nonstationarity could again lead to a poor performance of the estimator as lagged levels likely become weak instruments in the FOD-transformed model.
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